Peroxisomal retrograde signalling in stress; an alternate mechanistic dimension.

Peroxisomes are ubiquitous to all eukaryotes and play a vital role in growth, development as well as stress response in single- and multicellular microorganisms, plants and animals. Disorders attributed to peroxisome dysfunction can generally be divided into two different categories based on the defects in either the organelle formation or peroxisomal enzyme/ transporter proteins. Defects such as these are known to result in metabolic as well as immune disorders. They are also known to carry antiviral signalling proteins that can initiate the expression of multiple interferons stimulating genes. Recent studies including Rackles et al., are beginning to reveal that the role of peroxisomes in health and disease is much more complex than first thought.

Here, Rackles et al. revealed a peroxisomal retrograde pathway as an alternative signalling mechanisms, which was activated due to knockdown of a specific transporter during induced stress. The authors combine Lipidomic, transcriptomic and proteomic analyses to identify an array of proteins involved in peroxisomal lipid metabolism and immunity.

In Rackles et al., authors used IonOpticks Aurora Series emitter columns for both lipidomic and proteomics analysis, demonstrating the flexibility of sample types that can be used with these columns. From this work they identified a reduction in lipid metabolism in peroxisomes and identify potential new components of the peroxisomal retrograde signalling pathway.

Read the full paper
Reduced peroxisomal import triggers peroxisomal retrograde signaling.
Cell Reports. 34, no. 3 (2021): 108653. doi: https://www.cell.com/cell-reports/pdf/S2211-1247(20)31642-9.pdf
Rackles, Elisabeth, Michael Witting, Ignasi Forné, Xing Zhang, Judith Zacherl, Simon Schrott, Christian Fischer et al.

Commentary by Rida Rehman, PhD researcher.

About the author
Rida Rehman is a Ph.D. researcher in the field of neuroscience at Ulm, Germany. She is leading various research projects in the field of translational neuroscience. Rida is a science enthusiast and utilizes her past time as a scientific content creator believing in open science.