The secret interface of the neuroimmune system: the key to immune surveillance.

Neuroimmune interactions play a significant role in several neurological disorders and the current state-of-art suggests that central nervous system (CNS)-derived antigens are sorted and presented to circulating T cells. However, our understanding of the molecular mechanisms which regulate this CNS-immune interface under steady-state conditions remains relatively limited. Monitoring the molecular response of this interface under neuroinflammatory and neurodegenerative conditions will help to improve our understanding of disease pathogenesis and provide novel therapeutic strategies for these diseases.

In this impressive body of work, Rustenhoven et al. use IonOpticks Aurora Series columns to perform comprehensive proteomic characterisation of human and mouse dural samples. In particular, the study confirmed that dural sinuses represent a critical interface for immune-blood-brain interactions and highlighted the accumulation of a number of CNS-derived antigens, many of which were conserved between humans and mice. Moreover, the accumulation of MOG-reactive T cells as a response to neuroinflammation was identified. On the whole, this work demonstrates the true power of exploiting modern proteomics within a multi-disciplinary study and has helped to unravel the complex molecular mechanisms which drive regulation of neuroimmunity.

Read the full paper
Functional characterization of the dural sinuses as a neuroimmune interface.
Cell
. 2021 Feb 18;184(4):1000-1016.e27. doi: 10.1016/j.cell.2020.12.040. Epub 2021 Jan 27. PMID: 33508229.
Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J. 

Commentary by Andrew Webb, PhD.

About the author

Andrew has over 15 years’ experience in the field of chromatography and mass spectrometry. He is the lead innovator and inventor at IonOpticks, working closely with the team to test, refine and develop cutting edge techniques to support higher quality outputs and analytics from MS instruments. Andrew is also the Lab Head of the Walter and Eliza Hall Institute of Medical Research’s Proteomics Research Laboratory.