The publication “Slow TCA flux and ATP production in primary solid tumours but not metastases” in Nature reports that primary solid tumors exhibit reduced tricarboxylic acid (TCA) cycle flux and ATP production compared to normal tissue, whereas metastatic tumors do not show such differences. Using isotopic tracing and metabolic assays, the authors found that primary solid tumors utilize different metabolic pathways compared to metastatic tumors and postulate that this may contribute to their altered TCA flux and ATP production. Overall, the study provides new insights into tumor metabolism and could have implications for developing therapies that target specific metabolic pathways in cancer. The findings also highlight the importance of considering primary and metastatic tumors separately in cancer research.
Caroline R. Bartman, Daniel R. Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S. R. Jankowski, Laith Samarah, Noel R. Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn Davidson, Martin Wühr, Matthew G. Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang & Joshua D. Rabinowitz
Slow TCA flux and ATP production in primary solid tumours but not metastases