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Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes distinct pathogenesis in adults and children. In this study, researchers utilized our Aurora Elite column to support multiomics studies and combined this with chip-based mechanistic studies to investigate the immune response and blood proteome of severe COVID-19 patients, including both adults and children, to identify the differences in disease pathogenesis. The results showed that adults had higher levels of inflammatory markers and activation of immune cells, whereas children had higher levels of antiviral markers and immune response associated with wound healing. The findings suggest that the different pathogenesis of severe COVID-19 in adults and children is associated with distinct immune responses. Understanding the distinct drivers of the disease in different age groups can aid in the development of targeted therapies and improve patient outcomes.


This study utilized the IonOpticks 15cm Aurora Elite column

Journal Article – 04 April 2023 – Nature Communications

Authors

S. Druzak; E. Iffrig; B. R. Roberts; T. Zhang; K. S. Fibben; Y. Sakurai; H. P. Verkerke; C. A. Rostad; A. Chahroudi; F. Schneider

Title

Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19

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