Researchers have made significant strides in understanding the sexual reproduction of Toxoplasma gondii, a parasitic pathogen responsible for toxoplasmosis. They investigated the role of transcription factors AP2XII-1 and AP2XI-2 during the tachyzoite stage, a crucial phase in the parasite’s life cycle. The research provides insights into the epigenetic rewiring orchestrated by AP2XII-1 and AP2XI-2.

This study utilized IonOpticks 25cm columns for proteomic analysis, advancing our understanding of Toxoplasma’s sexual development without the need for cat as model organisms.

Nature, 13 Dec 2023, 625

Authors

A. V. Antunes; M. Shahinas; C. Swale; D. C. Farhat; C. Ramakrishnan; C. Bruley; D. Cannella; M. G. Robert; C. Corrao; Y. Couté; A. B. Hehl; A Bougdour; I. Coppens; MA. Hakimi

Title

In vitro production of cat-restricted Toxoplasma pre-sexual stages