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IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma

Presented here is the latest breakthrough in immunopeptidomics by Wahle et al. from the Mann lab. The Innovative Immunopeptidomics by Biotinylated Antibodies and Streptavidin (IMBAS-MS) workflow. This cutting-edge technology offers an automated, highly sensitive, and cost-effective solution for researchers. IMBAS-MS empowers you to quantify over 5000 HLA class I peptides using just 200 μl of plasma in a mere 30 minutes.

IMBAS-MS simplifies the immunopeptidomics process by replacing the traditional ProteinA/G affinity capture with the highly specific streptavidin-biotin interaction, significantly reducing hands-on time. Whether you’re in a specialized immunopeptidomics lab or a mass spectrometry-focused facility, IMBAS-MS is accessible and efficient.

Discover the broader applications of sHLA immunopeptidomics, from enhancing our understanding of immune mechanisms to advancing precision oncology research. With its minimal-invasive nature and streamlined workflow, IMBAS-MS holds promise for disease monitoring and personalized medicine, potentially enabling earlier interventions and more effective treatments. Explore the world of IMBAS-MS and its impact on immunology and clinical research today.



Published in Molecular & Cellular Proteomics

Authors

M. Wahle; M. Thielert; M. Zwiebel; P. Skowronek; W.-F. Zeng; M. Mann

Title

IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma

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