Amr S Abbadi, PhD candidate

Big data and structural proteomics allow epitope mapping of over 100,000 antigen-nanobody complexes.

Big data and structural proteomics allow epitope mapping of over 100,000 antigen-nanobody complexes.

The humoral antibody immune response is universal and critical for the survival of mammals, including humans. However, there is a lack of understanding of the antibody immune response mechanisms. Studying …

Big data and structural proteomics allow epitope mapping of over 100,000 antigen-nanobody complexes. Read More »

Ubiquitin ligase marks neo-substrates for degradation with unique Ub code.

Ubiquitin ligase marks neo-substrates for degradation with unique Ub code.

Targeted protein degradation has recently been studied as a possible therapeutic paradigm. Kaiho-Soma et al. were able to establish that the ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) accelerates …

Ubiquitin ligase marks neo-substrates for degradation with unique Ub code. Read More »