Andrew Webb, PhD

Killers that communicate: Cytotoxic T lymphocytes are capable of swarming to their tumour target.

Killers that communicate: Cytotoxic T lymphocytes are capable of swarming to their tumour target.

Cytotoxic T lymphocytes (CTLs) are a specialised form of killer cells which are capable of moving around the body, seeking out harmful cells, and removing them from the body before …

Killers that communicate: Cytotoxic T lymphocytes are capable of swarming to their tumour target. Read More »

The secret interface of the neuroimmune system: the key to immune surveillance.

The secret interface of the neuroimmune system: the key to immune surveillance.

Neuroimmune interactions play a significant role in several neurological disorders and the current state-of-art suggests that central nervous system (CNS)-derived antigens are sorted and presented to circulating T cells. However, …

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Getting to the heart of the matter: Comprehensive peptide & oxidation profiling in failing human hearts with UHPLC-MS.

Getting to the heart of the matter: Comprehensive peptide & oxidation profiling in failing human hearts with UHPLC-MS.

Diabetes, obesity, heart disease and ageing have all been strongly associated with oxidative stress. For heart disease in particular, the resultant oxidative protein damage caused has been directly linked to …

Getting to the heart of the matter: Comprehensive peptide & oxidation profiling in failing human hearts with UHPLC-MS. Read More »

Caught in the act: New CryoEM protein structure reveals the potential to drug antibiotic resistance.

Caught in the act: New CryoEM protein structure reveals the potential to drug antibiotic resistance.

How bacteria resistance can be spread between species of bacteria is understood to occur via a couple mechanisms. One of these such mechanisms involves cell surface proteins that can bind …

Caught in the act: New CryoEM protein structure reveals the potential to drug antibiotic resistance. Read More »

diaPASEF on the Bruker timsTOF Pro + Aurora Series columns provides unprecedented proteome analysis.

diaPASEF on the Bruker timsTOF Pro + Aurora Series columns provides unprecedented proteome analysis.

Over the last few years, mass spectrometry based proteomics workflows have become increasingly more powerful in capturing complex proteomes to incredible depths. This has largely been driven by the adoption …

diaPASEF on the Bruker timsTOF Pro + Aurora Series columns provides unprecedented proteome analysis. Read More »

An inflammatory messenger: Immunogenic exosome cargo in rheumatoid arthritis.

An inflammatory messenger: Immunogenic exosome cargo in rheumatoid arthritis.

Our understanding of the role exosomes play in disease progression continues to develop and highlights their research potential to not only provide new insights into disease mechanisms, but their enormous …

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Deep label free phosphoproteomics identifies novel mechanisms of kinase function.

Deep label free phosphoproteomics identifies novel mechanisms of kinase function.

RNA Polymerase is a multi-subunit enzyme that reads DNA and generates messenger RNA in the process known as transcription. Transcription, as the first step in gene expression, is tightly regulated …

Deep label free phosphoproteomics identifies novel mechanisms of kinase function. Read More »

Cysteine cross-linking analysis reveals new insights into growth factor receptor signalling.

Cysteine cross-linking analysis reveals new insights into growth factor receptor signalling.

Growth factors and their receptors are central in directing cell division, development and differentiation. Their role in controlling cell fate makes them one of the most hijacked protein classes during …

Cysteine cross-linking analysis reveals new insights into growth factor receptor signalling. Read More »

A new sensitive and accurate method enables endogenous phosphotyrosine mapping.

A new sensitive and accurate method enables endogenous phosphotyrosine mapping.

Phosphotyrosine (pTyr) plays a central role in many cell-to-cell communication pathways, including those that regulate proliferation, differentiation, adhesion, hormone responses, and immune defense. These pathways are commonly dysregulated in cancer …

A new sensitive and accurate method enables endogenous phosphotyrosine mapping. Read More »

Destructive relationships – Novel proteomic technique helps to define protein degradation complexes.

Destructive relationships – Novel proteomic technique helps to define protein degradation complexes.

The most common therapeutic strategy for drug development is the inhibition of enzymatic activity, which has many challenges, including the relatively limited protein repertoire available to be targeted (only 20-25% …

Destructive relationships – Novel proteomic technique helps to define protein degradation complexes. Read More »

Ion mobility assisted precursor selection benefits cross-linking mass spectrometry.

Ion mobility assisted precursor selection benefits cross-linking mass spectrometry.

Chemical cross-linking of interacting proteins locks them in place, and when combined with MS based proteomics, facilitates the identification of tertiary and quaternary structural information. This powerful approach allows researchers …

Ion mobility assisted precursor selection benefits cross-linking mass spectrometry. Read More »

4D Proteomics enabled Maxquant demonstrates unprecedented depth of coverage.

4D Proteomics enabled Maxquant demonstrates unprecedented depth of coverage.

The recent adoption of trapped ion mobility into the sensitive and ultra-high resolution Bruker TOF platform, has created a remarkably powerful instrument. The timsTOF Pro directly provides an accurate measure …

4D Proteomics enabled Maxquant demonstrates unprecedented depth of coverage. Read More »

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity.

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity.

G-protein-coupled receptors (GPCRs) are the largest and most diverse classes of membrane receptors in humans. These cell surface receptors act like the switchboard of the cell, communicating messages in the …

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity. Read More »