Aurora Series packed emitter columns are proudly setting a new standard of performance for leading mass specs. Having set an all new benchmark for what is possible, the Aurora Series …
Unlock the full potential of your mass spec with IonOpticks UHPLC columns Read More »
Cytotoxic T lymphocytes (CTLs) are a specialised form of killer cells which are capable of moving around the body, seeking out harmful cells, and removing them from the body before …
Neuroimmune interactions play a significant role in several neurological disorders and the current state-of-art suggests that central nervous system (CNS)-derived antigens are sorted and presented to circulating T cells. However, …
The secret interface of the neuroimmune system: the key to immune surveillance. Read More »
Plasma is a powerful reservoir of disease biomarkers for diagnostic, prognostic, and predictive purposes, flowing through each tissue in the body and accumulating vital information about the pathological state of …
Getting into the rhythm with large-scale profiling of the plasma proteome. Read More »
Diabetes, obesity, heart disease and ageing have all been strongly associated with oxidative stress. For heart disease in particular, the resultant oxidative protein damage caused has been directly linked to …
How bacteria resistance can be spread between species of bacteria is understood to occur via a couple mechanisms. One of these such mechanisms involves cell surface proteins that can bind …
Over the last few years, mass spectrometry based proteomics workflows have become increasingly more powerful in capturing complex proteomes to incredible depths. This has largely been driven by the adoption …
Our understanding of the role exosomes play in disease progression continues to develop and highlights their research potential to not only provide new insights into disease mechanisms, but their enormous …
An inflammatory messenger: Immunogenic exosome cargo in rheumatoid arthritis. Read More »
Dr Jarrod Sandow provides an overview of the beginnings of IonOpticks and our Aurora Series columns, currently the global leader in high-performance packed emitter columns.
The importance of exosomes in many facets of biology continues to grow, having been implicated in many fundamental processes of cellular and host function. Exosomes are small membrane encapsulated vesicles, …
Delivery with a killer message: Airway exosomes drive antiviral response. Read More »
Tumour Necrosis Factor (TNF) plays a central role in our body’s immune system, helping to control inflammation that occurs as our body responds to damage or infection. Cells often respond …
Releasing the brakes on immune responses by inhibition of HOIL-1L. Read More »
RNA Polymerase is a multi-subunit enzyme that reads DNA and generates messenger RNA in the process known as transcription. Transcription, as the first step in gene expression, is tightly regulated …
Deep label free phosphoproteomics identifies novel mechanisms of kinase function. Read More »
Growth factors and their receptors are central in directing cell division, development and differentiation. Their role in controlling cell fate makes them one of the most hijacked protein classes during …
The tumor microenvironment, made up of surrounding fibroblasts, immune cells and blood vessels, is much less studied and understood than the biology of the cancerous tissue itself. It is well …
Label free secretome analysis demonstrates microenvironment regulation of cancer. Read More »
Phosphotyrosine (pTyr) plays a central role in many cell-to-cell communication pathways, including those that regulate proliferation, differentiation, adhesion, hormone responses, and immune defense. These pathways are commonly dysregulated in cancer …
A new sensitive and accurate method enables endogenous phosphotyrosine mapping. Read More »
ASMS 2020 Reboot kicks off a two-week live program on June 1st! We’ve been busy preparing behind the scenes and look forward to sharing our revolutionary technology with the global …
The most common therapeutic strategy for drug development is the inhibition of enzymatic activity, which has many challenges, including the relatively limited protein repertoire available to be targeted (only 20-25% …
Chemical cross-linking of interacting proteins locks them in place, and when combined with MS based proteomics, facilitates the identification of tertiary and quaternary structural information. This powerful approach allows researchers …
Ion mobility assisted precursor selection benefits cross-linking mass spectrometry. Read More »
The recent adoption of trapped ion mobility into the sensitive and ultra-high resolution Bruker TOF platform, has created a remarkably powerful instrument. The timsTOF Pro directly provides an accurate measure …
4D Proteomics enabled Maxquant demonstrates unprecedented depth of coverage. Read More »
As one of the immune system’s first lines of defence, Natural Killer (NK) cells – are a crucial part of the autoimmune response that can prevent the growth and spread …
Aurora Series columns help identify NK cell role in defeating cancer. Read More »
G-protein-coupled receptors (GPCRs) are the largest and most diverse classes of membrane receptors in humans. These cell surface receptors act like the switchboard of the cell, communicating messages in the …
