Jarrod Sandow, PhD

Single-Cell Proteomics and the SCoPE2 method with Associate Professor Nikolai Slavov

Single-Cell Proteomics and the SCoPE2 method with Associate Professor Nikolai Slavov

I was fortunate to sit down with Associate Professor Nikolai Slavov to chat about the SCoPE2 method, an improvement on the previously developed SCoPE-MS method, using multiplexed LC-ESI-MS/MS for single-cell …

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diaPASEF: taking deep analysis of complex proteomes with DIA workflows into a new di(a)mension.

diaPASEF: taking deep analysis of complex proteomes with DIA workflows into a new di(a)mension.

In recent years mass spectrometry-based proteomics workflows have become ever more powerful in analysing complex proteomes to great depth. Data-independent acquisition (DIA) approaches are particularly attractive due to their reproducibility …

diaPASEF: taking deep analysis of complex proteomes with DIA workflows into a new di(a)mension. Read More »

SCoPE this out! Improved single-cell proteomics method exposes macrophage proteome heterogeneity.

SCoPE this out! Improved single-cell proteomics method exposes macrophage proteome heterogeneity.

The concept of tissues as heterogeneous populations of cell types with diverse phenotypes is now well recognised thanks to single-cell transcriptomics. Although individual cell specialisation often arises from protein-mediated physiology, …

SCoPE this out! Improved single-cell proteomics method exposes macrophage proteome heterogeneity. Read More »

Rapid sample analysis: Simplified high-throughput methods for deep proteome analysis on timsTOF Pro.

Rapid sample analysis: Simplified high-throughput methods for deep proteome analysis on timsTOF Pro.

Recent advances in mass spectrometry technology have seen remarkable increases in proteomic sequencing speed, while improvements to dynamic range have remained limited. An exemplar of this is the new timsTOF …

Rapid sample analysis: Simplified high-throughput methods for deep proteome analysis on timsTOF Pro. Read More »