Quantitative multiplexed proteomic techniques, such as TMT, are a powerful tool for analysing and quantifying proteins in a cell. These techniques rely on the quantification of reporter ions that are …
The Covid-19 pandemic is an ongoing global pandemic that has created an immense burden on health and economic systems globally, with 100s of millions of infections and millions of deaths …
Apoptosis is a highly regulated process of programmed cell death that occurs in multicellular organisms to eliminate unwanted and/or damaged cells. Apoptosis is therefore crucial for the maintenance of healthy …
Driving apoptosis; MIB2, an E3 ligase protein to the cockpit! Read More »
DNA typically forms a right-handed double helix under physiological conditions but can also form higher-order structures such as a G-quadruplex (G4), formed by guanine-rich nucleic acid sequences. About 10,000 of …
Mitochondria import almost their entire proteome from the cytoplasm by translocating precursor proteins through the translocase of the outer membrane (TOM) complex, embedded in the mitochondrial surface. The mitochondrial import …
Apart from 13 core subunits of the OXPHOS pathway, all the human mitochondrial proteome is encoded by the nuclear genome. Following synthesis on cytosolic ribosomes, proteins for mitochondrial function are …
