Muhammad Zenaidee, PhD

G4 nucleic acid structures act as extra-chromosomal inhibitors in ISG cancer gene regulation.

G4 nucleic acid structures act as extra-chromosomal inhibitors in ISG cancer gene regulation.

DNA typically forms a right-handed double helix under physiological conditions but can also form higher-order structures such as a G-quadruplex (G4), formed by guanine-rich nucleic acid sequences. About 10,000 of …

G4 nucleic acid structures act as extra-chromosomal inhibitors in ISG cancer gene regulation. Read More »

Club bouncer: the ubiquitin system dynamically regulates mitochondrial import at the TOM complex.

Club bouncer: the ubiquitin system dynamically regulates mitochondrial import at the TOM complex.

Mitochondria import almost their entire proteome from the cytoplasm by translocating precursor proteins through the translocase of the outer membrane (TOM) complex, embedded in the mitochondrial surface. The mitochondrial import …

Club bouncer: the ubiquitin system dynamically regulates mitochondrial import at the TOM complex. Read More »

Getting their ducks in a row – LONP1 co-chaperones with mtHSP70 in mitochondrial protein folding.

Getting their ducks in a row – LONP1 co-chaperones with mtHSP70 in mitochondrial protein folding.

Apart from 13 core subunits of the OXPHOS pathway, all the human mitochondrial proteome is encoded by the nuclear genome. Following synthesis on cytosolic ribosomes, proteins for mitochondrial function are …

Getting their ducks in a row – LONP1 co-chaperones with mtHSP70 in mitochondrial protein folding. Read More »