Publications

Plasma proteomics has advanced considerably, yet the field faces a critical challenge: the vast dynamic range of plasma proteins makes it difficult to detect low-abundance biomarkers that may hold diagnostic … Continued

Single-cell proteomics (SCP) holds enormous promise for resolving cellular heterogeneity at the protein level, yet the field remains limited by low sensitivity, incomplete proteome coverage, and high rates of missing … Continued

Graphical abstract. From Pañeda et al., 2026. “Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry.“ Cell Systems (2026). doi: https://doi.org/10.1016/j.cels.2026.101536; Licensed … Continued

Human induced pluripotent stem cells (iPSCs) can be differentiated into motor neurons (MNs), offering valuable models for studying neurodegenerative diseases such as ALS and SMA. While single-cell RNA sequencing has … Continued

Graphical summary of data collection and acquisition. Cropped from Foiani et al., 2026. “Spatial single-cell proteomics reveals molecular trajectories of tangle-bearing neurons in Alzheimer’s disease.“ bioRxiv (2026). doi: https://doi.org/10.64898/2026.04.26.720932; Licensed under the terms … Continued

Stress granules (SGs) are membrane-less cellular condensates that form in response to physiological stressors such as viral infection, hypoxia, and oxidative stress. Their dysregulation has been linked to neurodegeneration, cancer, … Continued

Ubiquitination (the attachment of a small protein tag called ubiquitin to cellular molecules) has long been understood as a mechanism for regulating protein function and degradation. However, mounting evidence suggested … Continued

Image from vecstock on Magnific Human blood plasma is one of the most diagnostically valuable biological samples available, yet its extreme protein dynamic range — spanning up to 10¹² — … Continued

The human genome encodes roughly 19,500 canonical protein-coding genes, but growing evidence suggests thousands of additional small proteins, called microproteins, are translated from non-canonical open reading frames (ncORFs) that reference … Continued

Graphical abstract. From Trendel et al., 2026. “Rapid photo-crosslinking in living cells reveals protein–nucleic acid dynamics on a timescale of minutes.“ Nucleic Acids Research (2026). doi: https://doi.org/10.1093/nar/gkag339; Licensed under the terms of the Creative … Continued

Understanding how glutamate receptors are organised in the human brain, and how that organisation changes in disease, has long been limited by the lack of tools capable of characterising receptor … Continued

Single cell proteomics (SCP) has advanced significantly for eukaryotic cells, enabling the identification of thousands of proteins per cell. However, bacteria present a far greater technical challenge: they are roughly … Continued

Image cropped from photoangel on Freepik Small extracellular vesicles (sEVs) are nanoscale, membrane-bound particles secreted by all cell types, carrying protein, lipid, and metabolite cargoes that reflect their cell of … Continued

Image cropped from pikisuperstar on Freepik Biological sex is a well-recognised driver of disease susceptibility, drug response, and immune function, yet its influence on protein glycosylation (a post-translational modification critical … Continued

Field Asymmetric Ion Mobility Spectrometry (FAIMS) is widely used in proteomics to enhance selectivity and reduce chemical noise, but traditional high-resolution settings limit peptide coverage due to narrow compensation voltage … Continued

Plasma proteomics has advanced considerably, yet the field faces a critical challenge: the vast dynamic range of plasma proteins makes it difficult to detect low-abundance biomarkers that may hold diagnostic … Continued

Quantitative proteomics has become essential for understanding protein expression across biological conditions, with data-independent acquisition (DIA) methods now enabling analysis of hundreds of samples daily. However, DIA data contains substantial … Continued

Vaccine development has historically overlooked human leukocyte antigen (HLA) diversity, resulting in vaccines that may be effective for some populations but fail to provide sufficient protection across the globe. HLA … Continued

Experimental scheme of the proteogenomic immunopeptidome analysis workflow. From Chemla et al., 2025. “HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion.“ Cell (2025). doi: 10.1016/j.cell.2025.11.020; Licensed under the … Continued

Overview of the PYE sample set and the study design. From Distler et al., 2025. “Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set.“ Nat … Continued

Schematic overview of the high-throughput hanging droplet workflow for micro-FFPE spatial proteomics. From Chen et al., 2025. “High-Throughput Spatial Proteomics at Cellular and Subcellular Resolution via a Hanging Droplet Workflow“, bioRxiv (2025): … Continued

Overview of the alphaDIA framework. From Wallmann et al., 2025. “AlphaDIA enables DIA transfer learning for feature-free proteomics“, Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02791-w; Licensed under the terms of the Creative Commons CC-BY 4.0 license. AlphaDIA … Continued

Graphical abstract. From Albrecht et al., 2025. “A Simplified Perchloric Acid Workflow With Neutralization (PCA N) for Democratizing Deep Plasma Proteomics at Population Scale“, Molecular & Cellular Proteomics, Volume 24, Issue … Continued

Visualisation of Slice-PASEF methods. From Sinn et al., 2025. “Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics“, bioRxiv (2025): 2025-09.; doi: https://doi.org/10.1101/2022.10.31.514544. Licensed under the terms of the Creative Commons CC-BY 4.0 license. Data-independent acquisition … Continued