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Deep label free phosphoproteomics identifies novel mechanisms of kinase function.

Deep label free phosphoproteomics identifies novel mechanisms of kinase function.

RNA Polymerase is a multi-subunit enzyme that reads DNA and generates messenger RNA in the process known as transcription. Transcription, as the first step in gene expression, is tightly regulated …

Deep label free phosphoproteomics identifies novel mechanisms of kinase function. Read More »

Cysteine cross-linking analysis reveals new insights into growth factor receptor signalling.

Cysteine cross-linking analysis reveals new insights into growth factor receptor signalling.

Growth factors and their receptors are central in directing cell division, development and differentiation. Their role in controlling cell fate makes them one of the most hijacked protein classes during …

Cysteine cross-linking analysis reveals new insights into growth factor receptor signalling. Read More »

A new sensitive and accurate method enables endogenous phosphotyrosine mapping.

A new sensitive and accurate method enables endogenous phosphotyrosine mapping.

Phosphotyrosine (pTyr) plays a central role in many cell-to-cell communication pathways, including those that regulate proliferation, differentiation, adhesion, hormone responses, and immune defense. These pathways are commonly dysregulated in cancer …

A new sensitive and accurate method enables endogenous phosphotyrosine mapping. Read More »

Destructive relationships – Novel proteomic technique helps to define protein degradation complexes.

Destructive relationships – Novel proteomic technique helps to define protein degradation complexes.

The most common therapeutic strategy for drug development is the inhibition of enzymatic activity, which has many challenges, including the relatively limited protein repertoire available to be targeted (only 20-25% …

Destructive relationships – Novel proteomic technique helps to define protein degradation complexes. Read More »

Ion mobility assisted precursor selection benefits cross-linking mass spectrometry.

Ion mobility assisted precursor selection benefits cross-linking mass spectrometry.

Chemical cross-linking of interacting proteins locks them in place, and when combined with MS based proteomics, facilitates the identification of tertiary and quaternary structural information. This powerful approach allows researchers …

Ion mobility assisted precursor selection benefits cross-linking mass spectrometry. Read More »

4D Proteomics enabled Maxquant demonstrates unprecedented depth of coverage.

4D Proteomics enabled Maxquant demonstrates unprecedented depth of coverage.

The recent adoption of trapped ion mobility into the sensitive and ultra-high resolution Bruker TOF platform, has created a remarkably powerful instrument. The timsTOF Pro directly provides an accurate measure …

4D Proteomics enabled Maxquant demonstrates unprecedented depth of coverage. Read More »

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity.

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity.

G-protein-coupled receptors (GPCRs) are the largest and most diverse classes of membrane receptors in humans. These cell surface receptors act like the switchboard of the cell, communicating messages in the …

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity. Read More »

Rapid sample analysis: Simplified high-throughput methods for deep proteome analysis on timsTOF Pro.

Rapid sample analysis: Simplified high-throughput methods for deep proteome analysis on timsTOF Pro.

Recent advances in mass spectrometry technology have seen remarkable increases in proteomic sequencing speed, while improvements to dynamic range have remained limited. An exemplar of this is the new timsTOF …

Rapid sample analysis: Simplified high-throughput methods for deep proteome analysis on timsTOF Pro. Read More »