phosphoproteomics

Targeted tyrosine phosphorylation profiling in precision oncology using SureQuant pTyr.

Targeted tyrosine phosphorylation profiling in precision oncology using SureQuant pTyr.

Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer, so profiling tumour pTyr levels may reveal therapeutic insights critical to combating disease. However, …

Targeted tyrosine phosphorylation profiling in precision oncology using SureQuant pTyr. Read More »

Phosphoproteomics with EasyPhos V2: Shorter workflow. Better sensitivity on limited starting material.

Phosphoproteomics with EasyPhos V2: Shorter workflow. Better sensitivity on limited starting material.

Mass spectrometry-based proteomics has transformed the study of cell signalling, enabling global studies of dynamic protein phosphorylation. A widespread post-translational modification, phosphorylation regulates almost all cellular processes, with two-thirds of …

Phosphoproteomics with EasyPhos V2: Shorter workflow. Better sensitivity on limited starting material. Read More »

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity.

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity.

G-protein-coupled receptors (GPCRs) are the largest and most diverse classes of membrane receptors in humans. These cell surface receptors act like the switchboard of the cell, communicating messages in the …

Phosphoproteomics using Aurora Series columns helps identify mechanisms of conformational plasticity. Read More »