quantitative proteomics Archives | IonOpticks

quantitative proteomics

MS3 for TMT, not me! TMTProC- improved MS2 accuracy and sensitivity using complementary ions.

10 October 2021

MS3 for TMT, not me! TMTProC- improved MS2 accuracy and sensitivity using complementary ions.

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Quantitative multiplexed proteomic techniques, such as TMT, are a powerful tool for analysing and quantifying proteins in a cell. These techniques rely on the quantification of reporter ions that are …

MS3 for TMT, not me! TMTProC- improved MS2 accuracy and sensitivity using complementary ions. Read More »

On chip: multiplexed low input TMT-labelled quantitative proteomics with digital microfluidics.

5 October 2021

On chip: multiplexed low input TMT-labelled quantitative proteomics with digital microfluidics.

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Digital microfluidics (DMF) technology facilitates miniaturised, automated, multiplexed liquid handling in multiple bioanalytical applications. However, in LC-MS-based proteomics its use has been limited to qualitative analysis, where the compatibility with …

On chip: multiplexed low input TMT-labelled quantitative proteomics with digital microfluidics. Read More »

Getting to the heart of the matter: Comprehensive peptide & oxidation profiling in failing human hearts with UHPLC-MS.

28 February 2021

Getting to the heart of the matter: Comprehensive peptide & oxidation profiling in failing human hearts with UHPLC-MS.

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Diabetes, obesity, heart disease and ageing have all been strongly associated with oxidative stress. For heart disease in particular, the resultant oxidative protein damage caused has been directly linked to …

Getting to the heart of the matter: Comprehensive peptide & oxidation profiling in failing human hearts with UHPLC-MS. Read More »