Cancer

PP2A, CDK9 transcription checkpoint interplay? Check! Targetable tumorigenesis inhibitor? Check!

PP2A, CDK9 transcription checkpoint interplay? Check! Targetable tumorigenesis inhibitor? Check!

RNA polymerase II (RNAPII)-driven transcription is a highly conserved process with distinct checkpoints, each controlled by dedicated transcriptional cyclin-dependent kinases (CDKs). CDK9 controls the pause-release checkpoint following transcription initiation. CDK …

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G4 nucleic acid structures act as extra-chromosomal inhibitors in ISG cancer gene regulation.

G4 nucleic acid structures act as extra-chromosomal inhibitors in ISG cancer gene regulation.

DNA typically forms a right-handed double helix under physiological conditions but can also form higher-order structures such as a G-quadruplex (G4), formed by guanine-rich nucleic acid sequences. About 10,000 of …

G4 nucleic acid structures act as extra-chromosomal inhibitors in ISG cancer gene regulation. Read More »

Targeted tyrosine phosphorylation profiling in precision oncology using SureQuant pTyr.

Targeted tyrosine phosphorylation profiling in precision oncology using SureQuant pTyr.

Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer, so profiling tumour pTyr levels may reveal therapeutic insights critical to combating disease. However, …

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Ubiquitin ligase marks neo-substrates for degradation with unique Ub code.

Ubiquitin ligase marks neo-substrates for degradation with unique Ub code.

Targeted protein degradation has recently been studied as a possible therapeutic paradigm. Kaiho-Soma et al. were able to establish that the ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) accelerates …

Ubiquitin ligase marks neo-substrates for degradation with unique Ub code. Read More »

Recombinant lectins as novel and efficient glycoproteomic tools.

Recombinant lectins as novel and efficient glycoproteomic tools.

Post-translational modifications (PTMs) are crucial biological processes implicated in multiple physiological and pathological pathways. Glycosylation is one such PTM that results in the attachment of glycans, which are chain-like structures …

Recombinant lectins as novel and efficient glycoproteomic tools. Read More »