RNA polymerase II (RNAPII)-driven transcription is a highly conserved process with distinct checkpoints, each controlled by dedicated transcriptional cyclin-dependent kinases (CDKs). CDK9 controls the pause-release checkpoint following transcription initiation. CDK …
Apoptosis is a highly regulated process of programmed cell death that occurs in multicellular organisms to eliminate unwanted and/or damaged cells. Apoptosis is therefore crucial for the maintenance of healthy …
Driving apoptosis; MIB2, an E3 ligase protein to the cockpit! Read More »
DNA typically forms a right-handed double helix under physiological conditions but can also form higher-order structures such as a G-quadruplex (G4), formed by guanine-rich nucleic acid sequences. About 10,000 of …
Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer, so profiling tumour pTyr levels may reveal therapeutic insights critical to combating disease. However, …
Targeted tyrosine phosphorylation profiling in precision oncology using SureQuant pTyr. Read More »
Targeted protein degradation has recently been studied as a possible therapeutic paradigm. Kaiho-Soma et al. were able to establish that the ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) accelerates …
Ubiquitin ligase marks neo-substrates for degradation with unique Ub code. Read More »
The interactome of membrane proteins are particularly interesting in cancer research as their involvement in pathways provide possible candidates for drug targets, as well as, understanding the molecular mechanisms involved …
Tumor suppressor PRELP membrane targets finally identified. Read More »
Post-translational modifications (PTMs) are crucial biological processes implicated in multiple physiological and pathological pathways. Glycosylation is one such PTM that results in the attachment of glycans, which are chain-like structures …
Recombinant lectins as novel and efficient glycoproteomic tools. Read More »
