This publication investigates the mechanism of how oxygen toxicity, related to excessive oxygen exposure, damages living cells. Researchers found that high levels of oxygen disrupt specific protein complexes containing iron-sulfur (Fe-S) clusters, leading to oxidative damage and cell death. The study, which utilizes our Aurora Elite column, shows how these protein complexes are essential for the survival of organisms, and the disruption of these clusters by oxygen toxicity is a crucial factor in many diseases. Understanding this mechanism could aid in developing therapies to protect against oxygen toxicity-related damage. The study provides insight into the fundamental process of cellular respiration and highlights the need for maintaining proper oxygen levels to maintain healthy cellular function.

This study utilized our Aurora Ultimate column, increasing sensitivity and coverage.

Read the full paper here – Journal Article – 2023 – Molecular Cell

Authors

A. H. Baik; A. G. Haribowo; X. Chen; B. B. Queliconi; A. M. Barrios; A. Garg; M. Maishan; A. R. Campos; M. A. Matthay; I. H. Jain

Title

Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes