Skip to content
Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes

This publication investigates the mechanism of how oxygen toxicity, related to excessive oxygen exposure, damages living cells. Researchers found that high levels of oxygen disrupt specific protein complexes containing iron-sulfur (Fe-S) clusters, leading to oxidative damage and cell death. The study, which utilizes our Aurora Elite column, shows how these protein complexes are essential for the survival of organisms, and the disruption of these clusters by oxygen toxicity is a crucial factor in many diseases. Understanding this mechanism could aid in developing therapies to protect against oxygen toxicity-related damage. The study provides insight into the fundamental process of cellular respiration and highlights the need for maintaining proper oxygen levels to maintain healthy cellular function.


This study utilized our Aurora Ultimate column, increasing sensitivity and coverage.

Read the full paper here – Journal Article – 2023 – Molecular Cell

Authors

A. H. Baik; A. G. Haribowo; X. Chen; B. B. Queliconi; A. M. Barrios; A. Garg; M. Maishan; A. R. Campos; M. A. Matthay; I. H. Jain

Title

Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes

Share:

Related publications & news

IN THIS EDITION: Big things are happening at IonOpticks. We’re excited to...
Patricia Skowronek, a postdoctoral researcher working with Prof. Matthias M...
World Immunization Week starts today! From the 24 to the 30 April 2024...
Melbourne, April 22 2024: IonOpticks has proudly been awarded a Silver Winn...
This groundbreaking study introduces a novel deep learning-based approach c...
In a groundbreaking study, researchers used Single Cell Proeomics to delve ...
Leduc et. al have developed nPOP, a revolutionary method for single-cell pr...
Presented here is the latest breakthrough in immunopeptidomics by Wahle et ...
Previous
Next
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.