A new study utilizing our Aurora Ultimate column published in Nature Cell Biology reveals that different chain lengths of sphingolipids play distinct roles in controlling insulin processing and glucose homeostasis. Griess et al. discovered that the balance between these sphingolipids was crucial for maintaining proper glucose levels in the body. The study provides important insights into the complex interplay between lipids and glucose metabolism, and highlights the potential for sphingolipid-targeted therapies for diabetes and other metabolic disorders. Overall, the findings expand our understanding of the role of sphingolipids in metabolic regulation and offer new avenues for therapeutic interventions.

Journal Article – 2023 – Nature Cell Biology

Authors

Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Miriam Cnop, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S. Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C. Brüning, Bengt-Frederik Belgardt

Title

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis