Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis | IonOpticks

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis

Dijana

28 August 2023
Publications / By

A new study utilizing our Aurora Ultimate column published in Nature Cell Biology reveals that different chain lengths of sphingolipids play distinct roles in controlling insulin processing and glucose homeostasis. Griess et al. discovered that the balance between these sphingolipids was crucial for maintaining proper glucose levels in the body. The study provides important insights into the complex interplay between lipids and glucose metabolism, and highlights the potential for sphingolipid-targeted therapies for diabetes and other metabolic disorders. Overall, the findings expand our understanding of the role of sphingolipids in metabolic regulation and offer new avenues for therapeutic interventions.

Journal Article – 2023 – Nature Cell Biology

Authors

Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Miriam Cnop, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S. Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C. Brüning, Bengt-Frederik Belgardt

Title

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis

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Byoung-Kyu Cho, Team Lead, Proteomics
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Washington University in St. Louis, School of Medicine

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We switched all our instruments with a 15 or 25cm aurora column for 1 year. Their performance, spray stability and robustness are really appreciated. We have really good results in label-free and DIA workflow compared to other columns used.

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Northeastern University

We obtained better results with IonOpticks...

 

We were able to leverage the very high accuracy of retention times as an additional feature to increase confidence in correct peptide identifications and to reduce confidence in incorrect ones.

Akinori Endo, PhD
Akinori Endo, PhD

Laboratory of Protein Metabolism
Tokyo Metropolitan Institute of Medical Science
Tokyo, Japan

We are very pleased with the performance of the Aurora column that can be applied to most proteomics studies. They allow us to acquire MS data with higher quality and especially improved in-depth proteomics output.

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Edinburgh Cancer Research UK Centre
Institute of Genetics and Molecular Medicine
University of Edinburgh

We have switched all our instruments from in-house packed 35cm emitters to Aurora columns. Their performance is equal or superior to our in-house packed columns, their spray-stability and durability is exceptional, they are fool-proof to install and last hundreds of runs.

Martin R. Larsen, PhD
Martin R. Larsen, PhD

Protein Research Group, University of Southern Denmark
Odense, Denmark

We have recently started to use the Aurora columns and they significantly outperform any other columns that we have ever used for nano-LC-MSMS, by providing much higher peptide coverage in proteomics and phosphoprotemics.

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Dr. Ignasi Forne

Ludwig-Maximilians-Universität
Planegg-Martinsried, Germany

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